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Normaalwaarden stollingsfactoren

Versie:
1
Publicatiedatum:
8 jul 2015
Auteur(s):
Mariëlle Wondergem, Clara Klerk

 

Factor

Naam

Hemostaseniveau*

Halfwaardetijd (uren)

I

Fibrinogeen

0.5 g/L

90

II

Protrombine

30 – 50%

60

III

Weefselfactor

IV

Calcium

V

Proaccereline

30%

15

VII

Proconvertine

10 – 30%

5

VIII

Antihemofilie-A-factor

20 – 50%

12

IX

Antihemofilie-B-factor

20 – 50%

20

X

Stuart – Prowerfactor

10 – 40%

40

XI

Antihemofilie-C-factor

20%

45

XII

Hagemanfactor

0%

50

XIII

Fibrine – stabiliserende – factor

1 – 5%

200

 

Prekalikreïne

0%

35

 

Hoogmoleculairkininogeen

0%

150

De referentiewaarden in plasma van de stollingsfactoren reiken van 60 – 150%; die van fibrinogen 2 – 4 g/L.

 

* De, minimale, hemostaseniveaus hebben vaak een wijd bereik, omdat zij afhankelijk zijn van

   de ernst van het trauma, de aard van de chirurgie e.d.

 Volgens bron: Leerboek chirurgie, H.A. Bruining et al. 1997.

 

Reference Values for Coagulation Tests in the Healthy Full – term Infant During the First 6 Months of Life.

Tests

Day 1

Day 5

Day 30

Day 90

Day 180

Adult**

PT (s)**

13.0 ± 1.43*

12.4 ± 1.46*†

11.8 ± 1.25*†

11.9 ± 1.15*

12.3 ± 0.79*

12.4 ± 0.78

APTT (s)**

42.9 ± 5.80

42.6 ± 8.62

40.4 ± 7.42

37.1 ± 6.52*

35.5 ± 3.71*

33.5 ± 3.44

TCT (s)**

23.5 ± 2.38*

23.1 ± 3.07†

24.3 ± 2.44*

25.1 ± 2.32*

25.5 ± 2.86*

25.0 ± 2.66

Fibrinogen** (g/L)

2.83 ± 0.58*

3.12 ± 0.75*

2.70 ± 0.54*

2.43 ± 0.68*

2.51 ± 0.68*†

2.78 ± 0.61

II (U/mL)

0.48 ± 0.11

0.63 ± 0.15

0.68 ± 0.17

0.75 ± 0.15

0.88 ± 0.14

1.08 ± 0.19

V (U/mL)

0.72 ± 0.18

0.95 ± 0.25

0.98 ± 0.18

0.90 ± 0.21

0.91 ± 0.18

1.06 ± 0.22

VII (U/mL)

0.66 ± 0.19

0.89 ± 0.27

0.90 ± 0.24

0.91 ± 0.26

0.87 ± 0.20

1.05 ± 0.19

VIII (U/mL)

1.00 ± 0.39*†

0.88 ± 0.33*†

0.91 ± 0.33*†

0.79 ± 0.23*†

0.73 ± 0.18†

0.99 ± 0.25

vWf (U/mL)

1.53 ± 0.67†

1.40 ± 0.57†

1.28 ± 0.59†

1.18 ± 0.44†

1.07 ± 0.45†

0.92 ± 0.33†

IX (U/mL)

0.53 ± 0.19

0.53 ± 0.19

0.51 ± 0.15

0.67 ± 0.23

0.86 ± 0.25

1.09 ± 0.27

X (U/mL)

0.40 ± 0.14

0.49 ± 0.15

0.59 ± 0.14

0.71 ± 0.18

0.78 ± 0.20

1.06 ± 0.23

XI (U/mL)

0.38 ± 0.14

0.55 ± 0.16

0.53 ± 0.13

0.69 ± 0.14

0.86 ± 0.24

0.97 ± 0.15

XII (U/mL)

0.53 ± 0.20

0.47 ± 0.18

0.49 ± 0.16

0.67 ± 0.21

0.77 ± 0.19

1.08 ± 0.28

PK (U/mL)

0.37 ± 0.16†

0.48 ± 0.14

0.57 ± 0.17

0.73 ± 0.16

0.86 ± 0.15

1.12 ± 0.25

HMW-K (U/mL)

0.54 ± 0.24

0.74 ± 0.28

0.77 ± 0.22*

0.82 ± 0.32*

0.82 ± 0.23*

0.92 ± 0.22

XIIIa

0.79 ± 0.26

0.94 ± 0.25*

0.93 ± 0.27*

1.04 ± 0.34*

1.04 ± 0.29*

1.05 ± 0.25

XIIIb

0.76 ± 0.23

1.06 ± 0.37*

1.11 ± 0.36*

1.16 ± 0.34*

1.10 ± 0.30*

0.97 ± 0.20

Plasminogen (CTA, U/mL)

1.95 ± 0.35

2.17 ± 0.38

1.98 ± 0.36

2.48 ± 0.37

3.01 ± 0.40

3.36 ± 0.44

All values are expressed as mean ± 1 SD.

 

*   Values do not differ statistically from the adult values.

†   These measurements are skewed because of a disproportionate number of high values.

     The lower limit for factor VIII was 0.50 U/mL at all time points for the infant.

** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende

     leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.

Bron: Andrew et al. Blood1987. 

 

Reference Values for the Inhibition of Coagulation in the Healthy Full-term Infant During the First 6 Months of Life

Inhibitors

Day 1

Day 5

Day 30

Day 90

Day 180

Adult**

AT – III

0.63 ± 0.12

0.67 ± 0.13

0.78 ± 0.15

0.97 ± 0.12*

1.04 ± 0.10*

1.05 ± 0.13

Alfa2 – M

1.39 ± 0.22

1.48 ± 0.25

1.50 ± 0.22

1.76 ± 0.25

1.91 ± 0.21

0.86 ± 0.17

Alfa2 – AP

0.85 ± 0.15

1.00 ± 0.15*

1.00 ± 0.12*

1.08 ± 0.16*

1.11 ± 0.14*

1.02 ± 0.17

C1E – inh

0.72 ± 0.18

0.90 ± 0.15*

0.89 ± 0.21

1.15 ± 0.22

1.41 ± 0.26

1.01 ± 0.15

Alfa1 – AT

0.93 ± 0.22*

0.89 ± 0.20*

0.62 ± 0.13

0.72 ± 0.15

0.77 ± 0.15

0.93 ± 0.19

HCII

0.43 ± 0.25

0.48 ± 0.24

0.47 ± 0.20

0.72 ± 0.37

1.20 ± 0.35

0.96 ± 0.15

Protein C

0.35 ± 0.09

0.42 ± 0.11

0.43 ± 0.11

0.54 ± 0.13

0.59 ± 0.11

0.96 ± 0.16

Protein S

0.36 ± 0.12

0.50 ± 0.14

0.63 ± 0.15

0.86 ± 0.16*

0.87 ± 0.16*

0.92 ± 0.16

All values are expressed as mean ± 1 SD.

 

*   Values do not differ statistically from the adult values.

** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende

     leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.

Bron: Andrew et al. Blood1987. 

 

Reference Values for Coagulation Tests in Healthy Premature Infants (30 to 36 Weeks Gestation) During the First 6 Months of Life

Tests

Day 1

Day 5

Day 30

Day 90

Day 180

Adults**

M

B

M

B

M

B

M

B

M

B

M

B

PT (s)**

13.0

10.6-16.2*

12.5

10.0-15.3*†

11.8

10.0-13.6*

12.3

10.0-14.6*

12.5

10.0-15.0*

12.4

10.8-13.9

APTT (s)**

53.6

27.5-79.4‡

50.5

26.9-74.1‡

44.7

26.9-62.5

39.5

28.3-50.7

37.5

21.7-53.3*

33.5

26.6-40.3

TCT (s)**

24.8

19.2-30.4*

24.1

18.8-29.4*

24.4

18.8-29.9*

25.1

19.4-30.8*

25.2

18.9-31.5*

25.0

19.7-30.3

Fibrinogen** (g/L)

2.43

1.50-3.73*†‡

2.80

1.60-4.18*†‡

2.54

1.50-4.14*†

2.46

1.50-3.52*†

2,28

1.50-3.60†

2.78

1.56-4.00

II (U/mL)

0.45

0.20-0.77†

0.57

0.29-0.85‡

0.57

0.36-0.95†‡

0.68

0.30-1.06

0.87

0.51-1.23

1.08

0.70-1.46

V (U/mL)

0.88

0.41-1.44*†‡

1.00

0.46-1.54

1.02

0.48-1.56

0.99

0.59-1.39

1.02

0.58-1.46

1.06

0.62-1.50

VII (U/mL)

0.67

0.21-1.13

0.84

0.30-1.38

0.83

0.21-1.45

0.87

0.31-1.43

0.99

0.47-1.51*

1.05

0.67-1.43

VIII (U/mL)

1.11

0.50-2.13*†

1.15

0.53-2.05*†‡

1.11

0.50-1.99*†‡

1.06

0.58-1.88*†‡

0.99

0.50-1.87*†‡

0.99

0.50-1.49

vWf (U/mL)

1.36

0.78-2.10†

1.33

0.72-2.19†

1.36

0.66-2.16†

1.12

0.75-1.84*†

0.98

0.54-1.58*†

0.92

0.50-1.58

IX (U/mL)

0.35

0.19-0.65†‡

0.42

0.14-0.74†‡

0.44

0.13-0.80†

0.59

0.25-0.93

0.81

0.50-1.20†

1.09

0.55-1.63

X (U/mL)

0.41

0.11-0.71

0.51

0.19-0.83

0.56

0.20-0.92

0.67

0.35-0.99

0.77

0.35-1.19

1.06

0.70-1.52

XI (U/mL)

0.30

0.08-0.52†‡

0.41

0.13-0.69‡

0.43

0.15-0.71‡

0.59

0.25-0.93‡

0.78

0.46-1.10

0.97

0.67-1.27

XII (U/mL)

0.38

0.10-0.66‡

0.39

0.09-0.69‡

0.43

0.11-0.75

0.61

0.15-1.07

0.82

0.22-1.42

1.08

0.52-1.64

PK (U/mL)

0.33

0.09-0.57

0.45

0.26-0.75†

0.59

0.31-0.87

0.79

0.37-1.21

0.78

0.40-1.16

1.12

0.62-1.62

HMW-K (U/mL)

0.49

0.09-0.89

0.62

0.24-1.00‡

0.64

0.16-1.12‡

0.78

0.32-1.24

0.83

0.41-1.25*

0.92

0.50-1.36

XIIIa (U/mL)

0.70

0.32-1.08

1.01

0.57-1.45*

0.99

0.51-1.47*

1.13

0.71-1.55*

1.13

0.65-1.61*

1.05

0.55-1.55

XIIIb (U/mL)

0.81

0.35-1.27

1.10

0.68-1.58*

1.07

0.57-1.57*

1.21

0.75-1.67

1.15

0.67-1.63

0.97

0.57-1.37

Plasminogen (CTA, U/mL)

1.70

1.12-2.48†‡

1.91

1.21-2.61‡

1.81

1.09-2.53

2.38

1.58-3.18

2.75

1.91-3.59‡

3.36

2.48-4.24

All values are given as mean (M) followed by lower and upper boundary encompassing 95% of the population (B).

 

*   Values indistinguishable from those of adults.

†   These measurements are skewed owing to a disproportionate number of high values.

     Lower limit which excludes the lower 2.5% of the population is given (B).

‡   Values different from those of fullterm infants.

** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende

     leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.

Bron: Andrew et al. Blood 1988. 

 

Reference Values for Inhibitors of Coagulation in Healthy Premature Infants During First 6 Months of Life

Tests

Day 1

Day 5

Day 30

Day 90

Day 180

Adults**

M

B

M

B

M

B

M

B

M

B

M

B

AT – III (U/mL)

0.38

0.14-0.62‡

0.56

0.30-0.82*

0.59

0.37-0.81‡

0.83

0.45-1.21‡

0.90

0.52-1.28‡

1.05

0.79-1.31

Alfa2 – M (U/mL)

1.10

0.56-1.82†‡

1.25

0.71-1.77*

1.38

0.72-2.04

1.80

1.20-2.66†

2.09

1.10-3.21†

0.86

0.52-1.20

Alfa2 – AP (U/mL)

0.78

0.40-1.16

0.81

0.49-1.13*

0.89

0.55-1.23‡

1.06

0.64-1.48*

1.15

0.77-1.53

1.02

0.68-1.36

C1E – inh (U/mL)

0.65

0.31-0.99

0.83

0.45-1.21

0.74

0.40-1.24†‡

1.14

0.60-1.68*

1.40

0.96-2.04†

1.01

0.71-1.31

Alfa1 – AT (U/mL)

0.90

0.36-1.44*

0.94

0.42-1.46‡

0.76

0.38-1.12‡

0.81

0.49-1.13*‡

0.82

0.48-1.16*

0.93

0.55-1.31

HCII (U/mL)

0.32

0.00-0.60‡

0.34

0.00-0.69*

0.43

0.15-0.71

0.61

0.20-1.11†

0.89

0.45-1.40*†‡

0.96

0.66-1.26

Protein C (U/mL)

0.28

0.12-0.44*‡

0.31

0.11-0.51*

0.37

0.15-0.59‡

0.45

0.23-0.67‡

0.57

0.31-0.83

0.96

0.64-1.28

Protein S (U/mL)

0.26

0.14-0.38‡

0.37

0.13-0.61*

0.56

0.22-0.90

0.76

0.40-1.12‡

0.82

0.44-1.20

0.92

0.60-1.24

All values are given as mean (M) followed by lower and upper boundary encompassing 95% of the population (B).

 

*   Values indistinguishable from those of adults.

†   These measurements are skewed owing to a disproportionate number of high values.

     Lower limit which excludes the lower 2.5% of the population is given (B).

‡   Values different from those of fullterm infants.

** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende

     leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.

Bron: Andrew et al. Blood 1988. 

 

Normaalwaarden stolling- en antistollingseiwitten tijdens zwangerschap

Stolfactor

Duur zwangerschap

1e trimester

2e trimester

3e trimester

Antitrombine

89 – 114

88 – 112

82 – 116

Factor V

75 – 95

72 – 96

60 – 88

Factor VII

100 – 146

95 – 153

149 – 211

Factor VIII

90 – 210

97 – 312

143 – 353

Factor IX

103 – 172

154 – 217

164 – 235

Factor XI

80 – 127

82 – 144

65 – 123

Factor XII

78 – 124

90 – 151

129 – 194

Fibrinogeen

2.4 – 5.1

2.9 – 5.4

3.7 – 6.1

Protein C

78 – 121

83 – 133

67 – 135

Protein S totaal

39 – 105

27 – 101

33 – 101

Protein S vrij

34 – 133

19 – 113

20 – 65

Bron: Abbassi-Ghanavati et al. Obstetrics & Gynecology 2009.