Factor |
Naam |
Hemostaseniveau* |
Halfwaardetijd (uren) |
I |
Fibrinogeen |
0.5 g/L |
90 |
II |
Protrombine |
30 – 50% |
60 |
III |
Weefselfactor |
– |
– |
IV |
Calcium |
– |
– |
V |
Proaccereline |
30% |
15 |
VII |
Proconvertine |
10 – 30% |
5 |
VIII |
Antihemofilie-A-factor |
20 – 50% |
12 |
IX |
Antihemofilie-B-factor |
20 – 50% |
20 |
X |
Stuart – Prowerfactor |
10 – 40% |
40 |
XI |
Antihemofilie-C-factor |
20% |
45 |
XII |
Hagemanfactor |
0% |
50 |
XIII |
Fibrine – stabiliserende – factor |
1 – 5% |
200 |
Prekalikreïne |
0% |
35 |
|
Hoogmoleculairkininogeen |
0% |
150 |
De referentiewaarden in plasma van de stollingsfactoren reiken van 60 – 150%; die van fibrinogen 2 – 4 g/L.
* De, minimale, hemostaseniveaus hebben vaak een wijd bereik, omdat zij afhankelijk zijn van
de ernst van het trauma, de aard van de chirurgie e.d.
Volgens bron: Leerboek chirurgie, H.A. Bruining et al. 1997.
Reference Values for Coagulation Tests in the Healthy Full – term Infant During the First 6 Months of Life.
Tests |
Day 1 |
Day 5 |
Day 30 |
Day 90 |
Day 180 |
Adult** |
PT (s)** |
13.0 ± 1.43* |
12.4 ± 1.46*† |
11.8 ± 1.25*† |
11.9 ± 1.15* |
12.3 ± 0.79* |
12.4 ± 0.78 |
APTT (s)** |
42.9 ± 5.80 |
42.6 ± 8.62 |
40.4 ± 7.42 |
37.1 ± 6.52* |
35.5 ± 3.71* |
33.5 ± 3.44 |
TCT (s)** |
23.5 ± 2.38* |
23.1 ± 3.07† |
24.3 ± 2.44* |
25.1 ± 2.32* |
25.5 ± 2.86* |
25.0 ± 2.66 |
Fibrinogen** (g/L) |
2.83 ± 0.58* |
3.12 ± 0.75* |
2.70 ± 0.54* |
2.43 ± 0.68* |
2.51 ± 0.68*† |
2.78 ± 0.61 |
II (U/mL) |
0.48 ± 0.11 |
0.63 ± 0.15 |
0.68 ± 0.17 |
0.75 ± 0.15 |
0.88 ± 0.14 |
1.08 ± 0.19 |
V (U/mL) |
0.72 ± 0.18 |
0.95 ± 0.25 |
0.98 ± 0.18 |
0.90 ± 0.21 |
0.91 ± 0.18 |
1.06 ± 0.22 |
VII (U/mL) |
0.66 ± 0.19 |
0.89 ± 0.27 |
0.90 ± 0.24 |
0.91 ± 0.26 |
0.87 ± 0.20 |
1.05 ± 0.19 |
VIII (U/mL) |
1.00 ± 0.39*† |
0.88 ± 0.33*† |
0.91 ± 0.33*† |
0.79 ± 0.23*† |
0.73 ± 0.18† |
0.99 ± 0.25 |
vWf (U/mL) |
1.53 ± 0.67† |
1.40 ± 0.57† |
1.28 ± 0.59† |
1.18 ± 0.44† |
1.07 ± 0.45† |
0.92 ± 0.33† |
IX (U/mL) |
0.53 ± 0.19 |
0.53 ± 0.19 |
0.51 ± 0.15 |
0.67 ± 0.23 |
0.86 ± 0.25 |
1.09 ± 0.27 |
X (U/mL) |
0.40 ± 0.14 |
0.49 ± 0.15 |
0.59 ± 0.14 |
0.71 ± 0.18 |
0.78 ± 0.20 |
1.06 ± 0.23 |
XI (U/mL) |
0.38 ± 0.14 |
0.55 ± 0.16 |
0.53 ± 0.13 |
0.69 ± 0.14 |
0.86 ± 0.24 |
0.97 ± 0.15 |
XII (U/mL) |
0.53 ± 0.20 |
0.47 ± 0.18 |
0.49 ± 0.16 |
0.67 ± 0.21 |
0.77 ± 0.19 |
1.08 ± 0.28 |
PK (U/mL) |
0.37 ± 0.16† |
0.48 ± 0.14 |
0.57 ± 0.17 |
0.73 ± 0.16 |
0.86 ± 0.15 |
1.12 ± 0.25 |
HMW-K (U/mL) |
0.54 ± 0.24 |
0.74 ± 0.28 |
0.77 ± 0.22* |
0.82 ± 0.32* |
0.82 ± 0.23* |
0.92 ± 0.22 |
XIIIa |
0.79 ± 0.26 |
0.94 ± 0.25* |
0.93 ± 0.27* |
1.04 ± 0.34* |
1.04 ± 0.29* |
1.05 ± 0.25 |
XIIIb |
0.76 ± 0.23 |
1.06 ± 0.37* |
1.11 ± 0.36* |
1.16 ± 0.34* |
1.10 ± 0.30* |
0.97 ± 0.20 |
Plasminogen (CTA, U/mL) |
1.95 ± 0.35 |
2.17 ± 0.38 |
1.98 ± 0.36 |
2.48 ± 0.37 |
3.01 ± 0.40 |
3.36 ± 0.44 |
All values are expressed as mean ± 1 SD.
* Values do not differ statistically from the adult values.
† These measurements are skewed because of a disproportionate number of high values.
The lower limit for factor VIII was 0.50 U/mL at all time points for the infant.
** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende
leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.
Bron: Andrew et al. Blood1987.
Reference Values for the Inhibition of Coagulation in the Healthy Full-term Infant During the First 6 Months of Life
Inhibitors |
Day 1 |
Day 5 |
Day 30 |
Day 90 |
Day 180 |
Adult** |
AT – III |
0.63 ± 0.12 |
0.67 ± 0.13 |
0.78 ± 0.15 |
0.97 ± 0.12* |
1.04 ± 0.10* |
1.05 ± 0.13 |
Alfa2 – M |
1.39 ± 0.22 |
1.48 ± 0.25 |
1.50 ± 0.22 |
1.76 ± 0.25 |
1.91 ± 0.21 |
0.86 ± 0.17 |
Alfa2 – AP |
0.85 ± 0.15 |
1.00 ± 0.15* |
1.00 ± 0.12* |
1.08 ± 0.16* |
1.11 ± 0.14* |
1.02 ± 0.17 |
C1E – inh |
0.72 ± 0.18 |
0.90 ± 0.15* |
0.89 ± 0.21 |
1.15 ± 0.22 |
1.41 ± 0.26 |
1.01 ± 0.15 |
Alfa1 – AT |
0.93 ± 0.22* |
0.89 ± 0.20* |
0.62 ± 0.13 |
0.72 ± 0.15 |
0.77 ± 0.15 |
0.93 ± 0.19 |
HCII |
0.43 ± 0.25 |
0.48 ± 0.24 |
0.47 ± 0.20 |
0.72 ± 0.37 |
1.20 ± 0.35 |
0.96 ± 0.15 |
Protein C |
0.35 ± 0.09 |
0.42 ± 0.11 |
0.43 ± 0.11 |
0.54 ± 0.13 |
0.59 ± 0.11 |
0.96 ± 0.16 |
Protein S |
0.36 ± 0.12 |
0.50 ± 0.14 |
0.63 ± 0.15 |
0.86 ± 0.16* |
0.87 ± 0.16* |
0.92 ± 0.16 |
All values are expressed as mean ± 1 SD.
* Values do not differ statistically from the adult values.
** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende
leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.
Bron: Andrew et al. Blood1987.
Reference Values for Coagulation Tests in Healthy Premature Infants (30 to 36 Weeks Gestation) During the First 6 Months of Life
Tests |
Day 1 |
Day 5 |
Day 30 |
Day 90 |
Day 180 |
Adults** |
||||||
M |
B |
M |
B |
M |
B |
M |
B |
M |
B |
M |
B |
|
PT (s)** |
13.0 |
10.6-16.2* |
12.5 |
10.0-15.3*† |
11.8 |
10.0-13.6* |
12.3 |
10.0-14.6* |
12.5 |
10.0-15.0* |
12.4 |
10.8-13.9 |
APTT (s)** |
53.6 |
27.5-79.4‡ |
50.5 |
26.9-74.1‡ |
44.7 |
26.9-62.5 |
39.5 |
28.3-50.7 |
37.5 |
21.7-53.3* |
33.5 |
26.6-40.3 |
TCT (s)** |
24.8 |
19.2-30.4* |
24.1 |
18.8-29.4* |
24.4 |
18.8-29.9* |
25.1 |
19.4-30.8* |
25.2 |
18.9-31.5* |
25.0 |
19.7-30.3 |
Fibrinogen** (g/L) |
2.43 |
1.50-3.73*†‡ |
2.80 |
1.60-4.18*†‡ |
2.54 |
1.50-4.14*† |
2.46 |
1.50-3.52*† |
2,28 |
1.50-3.60† |
2.78 |
1.56-4.00 |
II (U/mL) |
0.45 |
0.20-0.77† |
0.57 |
0.29-0.85‡ |
0.57 |
0.36-0.95†‡ |
0.68 |
0.30-1.06 |
0.87 |
0.51-1.23 |
1.08 |
0.70-1.46 |
V (U/mL) |
0.88 |
0.41-1.44*†‡ |
1.00 |
0.46-1.54 |
1.02 |
0.48-1.56 |
0.99 |
0.59-1.39 |
1.02 |
0.58-1.46 |
1.06 |
0.62-1.50 |
VII (U/mL) |
0.67 |
0.21-1.13 |
0.84 |
0.30-1.38 |
0.83 |
0.21-1.45 |
0.87 |
0.31-1.43 |
0.99 |
0.47-1.51* |
1.05 |
0.67-1.43 |
VIII (U/mL) |
1.11 |
0.50-2.13*† |
1.15 |
0.53-2.05*†‡ |
1.11 |
0.50-1.99*†‡ |
1.06 |
0.58-1.88*†‡ |
0.99 |
0.50-1.87*†‡ |
0.99 |
0.50-1.49 |
vWf (U/mL) |
1.36 |
0.78-2.10† |
1.33 |
0.72-2.19† |
1.36 |
0.66-2.16† |
1.12 |
0.75-1.84*† |
0.98 |
0.54-1.58*† |
0.92 |
0.50-1.58 |
IX (U/mL) |
0.35 |
0.19-0.65†‡ |
0.42 |
0.14-0.74†‡ |
0.44 |
0.13-0.80† |
0.59 |
0.25-0.93 |
0.81 |
0.50-1.20† |
1.09 |
0.55-1.63 |
X (U/mL) |
0.41 |
0.11-0.71 |
0.51 |
0.19-0.83 |
0.56 |
0.20-0.92 |
0.67 |
0.35-0.99 |
0.77 |
0.35-1.19 |
1.06 |
0.70-1.52 |
XI (U/mL) |
0.30 |
0.08-0.52†‡ |
0.41 |
0.13-0.69‡ |
0.43 |
0.15-0.71‡ |
0.59 |
0.25-0.93‡ |
0.78 |
0.46-1.10 |
0.97 |
0.67-1.27 |
XII (U/mL) |
0.38 |
0.10-0.66‡ |
0.39 |
0.09-0.69‡ |
0.43 |
0.11-0.75 |
0.61 |
0.15-1.07 |
0.82 |
0.22-1.42 |
1.08 |
0.52-1.64 |
PK (U/mL) |
0.33 |
0.09-0.57 |
0.45 |
0.26-0.75† |
0.59 |
0.31-0.87 |
0.79 |
0.37-1.21 |
0.78 |
0.40-1.16 |
1.12 |
0.62-1.62 |
HMW-K (U/mL) |
0.49 |
0.09-0.89 |
0.62 |
0.24-1.00‡ |
0.64 |
0.16-1.12‡ |
0.78 |
0.32-1.24 |
0.83 |
0.41-1.25* |
0.92 |
0.50-1.36 |
XIIIa (U/mL) |
0.70 |
0.32-1.08 |
1.01 |
0.57-1.45* |
0.99 |
0.51-1.47* |
1.13 |
0.71-1.55* |
1.13 |
0.65-1.61* |
1.05 |
0.55-1.55 |
XIIIb (U/mL) |
0.81 |
0.35-1.27 |
1.10 |
0.68-1.58* |
1.07 |
0.57-1.57* |
1.21 |
0.75-1.67 |
1.15 |
0.67-1.63 |
0.97 |
0.57-1.37 |
Plasminogen (CTA, U/mL) |
1.70 |
1.12-2.48†‡ |
1.91 |
1.21-2.61‡ |
1.81 |
1.09-2.53 |
2.38 |
1.58-3.18 |
2.75 |
1.91-3.59‡ |
3.36 |
2.48-4.24 |
All values are given as mean (M) followed by lower and upper boundary encompassing 95% of the population (B).
* Values indistinguishable from those of adults.
† These measurements are skewed owing to a disproportionate number of high values.
Lower limit which excludes the lower 2.5% of the population is given (B).
‡ Values different from those of fullterm infants.
** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende
leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.
Bron: Andrew et al. Blood 1988.
Reference Values for Inhibitors of Coagulation in Healthy Premature Infants During First 6 Months of Life
Tests |
Day 1 |
Day 5 |
Day 30 |
Day 90 |
Day 180 |
Adults** |
||||||
M |
B |
M |
B |
M |
B |
M |
B |
M |
B |
M |
B |
|
AT – III (U/mL) |
0.38 |
0.14-0.62‡ |
0.56 |
0.30-0.82* |
0.59 |
0.37-0.81‡ |
0.83 |
0.45-1.21‡ |
0.90 |
0.52-1.28‡ |
1.05 |
0.79-1.31 |
Alfa2 – M (U/mL) |
1.10 |
0.56-1.82†‡ |
1.25 |
0.71-1.77* |
1.38 |
0.72-2.04 |
1.80 |
1.20-2.66† |
2.09 |
1.10-3.21† |
0.86 |
0.52-1.20 |
Alfa2 – AP (U/mL) |
0.78 |
0.40-1.16 |
0.81 |
0.49-1.13* |
0.89 |
0.55-1.23‡ |
1.06 |
0.64-1.48* |
1.15 |
0.77-1.53 |
1.02 |
0.68-1.36 |
C1E – inh (U/mL) |
0.65 |
0.31-0.99 |
0.83 |
0.45-1.21 |
0.74 |
0.40-1.24†‡ |
1.14 |
0.60-1.68* |
1.40 |
0.96-2.04† |
1.01 |
0.71-1.31 |
Alfa1 – AT (U/mL) |
0.90 |
0.36-1.44* |
0.94 |
0.42-1.46‡ |
0.76 |
0.38-1.12‡ |
0.81 |
0.49-1.13*‡ |
0.82 |
0.48-1.16* |
0.93 |
0.55-1.31 |
HCII (U/mL) |
0.32 |
0.00-0.60‡ |
0.34 |
0.00-0.69* |
0.43 |
0.15-0.71 |
0.61 |
0.20-1.11† |
0.89 |
0.45-1.40*†‡ |
0.96 |
0.66-1.26 |
Protein C (U/mL) |
0.28 |
0.12-0.44*‡ |
0.31 |
0.11-0.51* |
0.37 |
0.15-0.59‡ |
0.45 |
0.23-0.67‡ |
0.57 |
0.31-0.83 |
0.96 |
0.64-1.28 |
Protein S (U/mL) |
0.26 |
0.14-0.38‡ |
0.37 |
0.13-0.61* |
0.56 |
0.22-0.90 |
0.76 |
0.40-1.12‡ |
0.82 |
0.44-1.20 |
0.92 |
0.60-1.24 |
All values are given as mean (M) followed by lower and upper boundary encompassing 95% of the population (B).
* Values indistinguishable from those of adults.
† These measurements are skewed owing to a disproportionate number of high values.
Lower limit which excludes the lower 2.5% of the population is given (B).
‡ Values different from those of fullterm infants.
** Deze waarden verschillen van lab tot lab. Hierbij is m.n. de mate van spreiding bij verschillende
leeftijden illustratief. Ons lab hanteert andere normaalwaarden voor volwassenen.
Bron: Andrew et al. Blood 1988.
Normaalwaarden stolling- en antistollingseiwitten tijdens zwangerschap
Stolfactor |
Duur zwangerschap |
||
1e trimester |
2e trimester |
3e trimester |
|
Antitrombine |
89 – 114 |
88 – 112 |
82 – 116 |
Factor V |
75 – 95 |
72 – 96 |
60 – 88 |
Factor VII |
100 – 146 |
95 – 153 |
149 – 211 |
Factor VIII |
90 – 210 |
97 – 312 |
143 – 353 |
Factor IX |
103 – 172 |
154 – 217 |
164 – 235 |
Factor XI |
80 – 127 |
82 – 144 |
65 – 123 |
Factor XII |
78 – 124 |
90 – 151 |
129 – 194 |
Fibrinogeen |
2.4 – 5.1 |
2.9 – 5.4 |
3.7 – 6.1 |
Protein C |
78 – 121 |
83 – 133 |
67 – 135 |
Protein S totaal |
39 – 105 |
27 – 101 |
33 – 101 |
Protein S vrij |
34 – 133 |
19 – 113 |
20 – 65 |
Bron: Abbassi-Ghanavati et al. Obstetrics & Gynecology 2009.